Spice up dinnertime with this irresistibly flavorful Cajun Meatloaf! Packed with a savory blend of ground beef and Italian sausage, this recipe takes a classic comfort food to bold new heights with the dynamic kick of Cajun seasoning, smoky paprika, and a tangy-sweet ketchup glaze. Finely chopped onions, green bell peppers, and celery add a traditional Creole touch known as the “holy trinity,” while Worcestershire sauce and apple cider vinegar provide a subtle depth of flavor. Perfectly baked to tender, juicy perfection, this meatloaf pairs beautifully with creamy mashed potatoes or roasted veggies. Quick to prep and irresistibly satisfying, Cajun Meatloaf is the ultimate weeknight dinner to satisfy spice lovers and comfort food fans alike!
Preheat your oven to 375°F (190°C) and lightly grease a loaf pan.
In a large skillet, heat a small amount of oil over medium heat. Add the chopped onion, green bell pepper, and celery, and sauté until softened, about 5 minutes. Add the minced garlic and cook for another minute. Set aside to cool.
In a large mixing bowl, combine the ground beef, Italian sausage, breadcrumbs, milk, eggs, Cajun seasoning, paprika, black pepper, Worcestershire sauce, and the cooked vegetable mixture. Mix gently with your hands or a wooden spoon until all ingredients are fully incorporated, being careful not to overmix.
Transfer the meat mixture to the prepared loaf pan, pressing it down gently to shape it evenly.
In a small bowl, whisk together the ketchup, brown sugar, and apple cider vinegar to make the glaze.
Spread the glaze evenly over the top of the meatloaf.
Place the loaf pan in the preheated oven and bake for about 50-60 minutes, or until the internal temperature reads 160°F (71°C) on a meat thermometer.
Let the meatloaf rest in the pan for 10 minutes before slicing and serving. Enjoy your Cajun Meatloaf with mashed potatoes or your favorite side dish!
Calories |
3404 | ||
|---|---|---|---|
% Daily Value* |
|||
| Total Fat | 214.4 g | 275% | |
| Saturated Fat | 82.9 g | 415% | |
| Polyunsaturated Fat | 11.3 g | ||
| Cholesterol | 1175 mg | 392% | |
| Sodium | 8974 mg | 390% | |
| Total Carbohydrate | 170.8 g | 62% | |
| Dietary Fiber | 12.7 g | 45% | |
| Total Sugars | 65.6 g | ||
| Protein | 229.0 g | 458% | |
| Vitamin D | 7.1 mcg | 35% | |
| Calcium | 490 mg | 38% | |
| Iron | 29.9 mg | 166% | |
| Potassium | 3984 mg | 85% | |
*The % Daily Value tells you how much a nutrient in a serving of food contributes to a daily diet. 2,000 calories a day is used for general nutrition advice.